Übersichtsarbeit

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„Laser-assisted drug delivery“: Ein neues Konzept in der Dermatopharmakotherapie

„Laser-assisted drug delivery“: A new concept in dermatopharmacotherapy

Keywords | Summary | Correspondence | Literature

Keywords

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Schlüsselworte

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Summary

The topical application of pharmacologic agents is an essential part of dermatotherapy. Yet, the (dermal) bioavailability of topically applied drugs is often limited due to the effective barrier function of the stratum corneum. Down this line various more or less successful strategies have been developed to overcome the epidermal barrier. Fractional ablative lasers represent a novel technology that enables a standardized, contact- free penetration of the epidermis, and allow us to increase the bioavailability of topically applied drugs by means of a laser assisted drug delivery (LADD). Here, we present an overview of established as well as perspective applications of LADD in the clinical practice.

Zusammenfassung

Die Behandlung von Hauterkrankungen durch topisch applizierte Externa stellt eine der wichtigsten Therapieoptionen in der Dermatologie dar. Auf Grund der oftmals geringen Bioverfügbarkeit von Lokaltherapeutika wurden bisher zahlreiche Methoden entwickelt die Penetration der Substanzen zu verbessern. Fraktionale ablative Laser stellen ein neuartiges, elegantes Verfahren dar, die dermale Barriere in einer definierten und kontrollierten Art und Weise kontaktfrei zu überwinden, um somit die Penetration von lokal applizierten Pharmaka zu erhöhen und deren dermale Bioverfügbarkeit im Sinne einer laser assisted drug delivery (LADD) zu steigern. Die vorliegende Arbeit bietet einen .berblick über die aktuellen aber auch perspektivischen Einsatzmöglichkeiten der LADD.

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Korrespondenz-Adresse

Dr. med. P. A. Gerber, D.A.L.M.
Hautklinik Universit.tsklinikum Düsseldorf
Moorenstra.e 5
D-40225 Düsseldorf
peterarne.gerber@med.uni-duesseldorf.de

Conflict of Interests

PAG hat Honorare der Firma Asclepion Laser Technologies erhalten. PAG hat finanzielle Unterstützung für Forschungsvorhaben durch die Firma Galderma erhalten. PAG und SAB haben finanzielle Unterstützung für Forschungsvorhaben durch die Firma Leo Pharma erhalten. SAB hat Reisekostenunterstützungen der Firma Biofrontera erhalten.

Literatur

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