Originalie
Ilja L. Kruglikov
Entdeckung der Zelltransformationen in der Haut markiert beginn einer neuen Ära in der Dermatologie und Ästhetischen Medizin
DISCOVERY OF CELL TRANSFORMATIONS IN THE SKIN MARKS BEGIN OF A NEW ERA IN DERMATOLOGY AND AESTHETIC MEDICINE
Keywords | Summary | Correspondence | Literature
Keywords
acne, de-differentiation, Dermal adipocytes, hair follicle cycle, myofibroblasts, Psoriasis, re-differentiation, scars, skin aging, trans-differentiation
Schlüsselworte
Akne, Dedifferenzierung, Dermale Adipozyten, Haarfollikel-Zyklus, Hautalterung, Myofibroblasten, Narben, Psoriasis, Redifferenzierung, Transdifferenzierung
Summary
Recently discovered recurrent de- and re-differentiations of mature dermal adipocytes located at the dermis-subcutis interface as well as trans-differentiation of these cells in myofibroblasts will have serious consequences for dermatology and aesthetic medicine. These processes are strongly dependent on the phase of the hair follicle cycle and should be at least involved in acne, psoriasis, wound healing, fibrosis / scarring, androgenetic alopecia, and skin aging.
Zusammenfassung
Neueste Entdeckung der wiederkehrenden De- und Redifferenzierungen der reifen dermalen Adipozyten an der Grenze Dermis-Subkutis sowie ihrer Transdifferenzierung in Myofibroblasten wird gravierende Konsequenzen für die Dermatologie und ästhetische Medizin haben. Diese Prozesse sind stark von der Phase des Haarfollikel-Zyklus abhängig und müssen in die Akne, Psoriasis, Wundheilung, Fibrosierung / Narbenbildung, androgenetische Alopezie und Hautalterung involviert werden.
Leider haben Sie sich nicht eingeloggt, um den Beitrag lesen zu können. Bitte loggen Sie sich ein oder beantragen Sie Ihre Zugangsberechtigung. Vielen Dank. Weitere Informationen finden Sie hier>
Korrespondenz-Adresse
Dr. rer. nat. habil. Ilja L. Kruglikov
Wellcomet GmbH
Greschbachstraße 2-4
DE-76229 Karlsruhe
i.kruglikov@wellcomet.de
Conflict of Interests
Dr. I. Kruglikov ist der geschäftsführende Gesellschafter der Firma Wellcomet GmbH. Wellcomet GmbH hat die Vorbereitung von diesem Artikel nicht beeinflusst.
Literatur
1. Kruglikov IL (2016) Dermale Adipozyten in Dermatologie und Ästhetischer Medizin: Fakten und Hypothesen. Kosmet Med 37(2): 52-59.
2. Zhang Z, Shao M, Hepler C, Zi Z, Zhao S, An YA, Zhu Y, Ghaben A, Wang MY, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Kumar A, Xing C, Wang QA, Deng Y, Gordillo R, Kruglikov IL, Kusminski CM, Gupta R, Scherer PE (2019) Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice. J Clin Invest 129(12): 5327- 5342.
3. Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, Gupta RK, Deplancke B, Scherer PE (2018) Reversible de-differentiation of mature white adipocytes into preadipocyte-like precursors during lactation. Cell Metab 28: 282-288.
4. Van Scott EJ, MacCardle RC (1956) Keratinization of the duct of the sebaceous gland and growth cycle of the hair follicle in the histogenesis of acne in human skin. J Invest Dermatol 27(6): 405-429.
5. Moon J, Yoon JY, Yang JH, Kwon HH, Min S, Suh DH (2019) Atrophic acne scar: A process from altered metabolism of elastic fibers and collagen fibers based on TGF‐β1 signaling. Br J Dermatol 181(6):1226-1237.
6. Kasumagić-Halilović E, Prohić A, Begović B (2010) TrichoScan as a method to determine hair root pattern in patients with scalp psoriasis. Acta Dermatovenerol Croat 18(3): 146-150.
7. Kruglikov IL, Scherer PE (2016) Dermal adipocytes and hair cycling: is spatial heterogeneity a characteristic feature of the dermal adipose tissue depot? Exp Dermatol 25(4): 258-262.
8. Kruglikov IL, Scherer PE, Wollina U (2016) Are dermal adipocytes involved in psoriasis? Exp Dermatol 25(10): 812-813.
9. Kruglikov IL, Wollina U (2017) Local effects of adipose tissue in psoriasis and psoriatic arthritis. Psoriasis (Auckland, NZ) 7: 17-25.
10. Kruglikov IL, Wollina U (2018) The role of subcutaneous adipose tissue in psoriasis. J Biol Regul Homeost Agents 32(1): 159-161.
11. Gao Y, Zhou J, Xie Z, Wang J, Ho CK, Zhang Y, Li Q (2019) Mechanical strain promotes skin fibrosis through LRG-1 induction mediated by ELK1 and ERK signalling. Commun Biol 2: 359.
12. Kruglikov IL, Zhang Z, Scherer PE (2019) Caveolin in skin aging. From innocent bystander to major contributor. Ageing Res Rev 55: 100959.
13. Zhang LJ, Chen SX, Guerrero-Juarez CF, Li F, Tong Y, Liang Y, Liggins M, Chen X, Chen H, Li M, Hata T, Zheng Y, Olikus MV, Gallo RL (2019) Age-related loss of innate immune antimicrobial function of dermal fat is mediated by transforming growth factor beta. Immunity 50(1): 121-136.
14. Kruglikov IL, Scherer PE (2016) Skin aging: are adipocytes the next target? Aging (Albany NY) 8: 1457-1469.
15. Liggins MC, Li F, Zhang LJ, Dokoshi T, Gallo RL (2019) Retinoids enhance the expression of cathelicidin antimicrobial peptide during reactive dermal adipogenesis. J Immunol 203: 1589-1597.
16. Kruglikov IL, Scherer PE (2019) Caveolin-1 as a pathophysiological factor and target in
psoriasis. npj Aging Mech Dis 5(1): 4.
17. Kruglikov IL, Scherer PE (2019) Caveolin-1 as a target in prevention and treatment of
hypertrophic scarring. npj Regen Med 4(1): 9.
18. Kruglikov IL, Scherer PE (2019) Caveolin‐1 as a possible target in treatment for acne. Exp Dermatol 29(2): 177-183.
19. Kruglikov IL, Scherer PE (2020) Caveolin as a universal target in dermatology. Int J Mol Sci 21(1): 80.
20. Kruglikov IL, Scherer PE (2018) Skin aging as a mechanical phenomenon: The main weak links. Nutr Healthy Aging 4(4): 291-307.
21. Kruglikov IL (2018) Hautalterung als mechanisches Phänomen: Was sind die wichtigsten Schwachstellen der Haut bei ihrer Alterung? Kosmet Med 39(3): 24-30.
22. Kruglikov IL (2015) Sehr hochfrequenter Ultraschall. Der Hautarzt. 66(11): 829-833.
23. Kruglikov IL (2018) Sehr hochfrequenter Ultraschall in der ästhetischen Medizin und Chirurgie. Ästhet Dermatol Kosmet 11(2): 27-31.
24. Kruglikov IL (2016) Influence of the dermis thickness on the results of the skin treatment with monopolar and bipolar radiofrequency currents. BioMed Res Int 2016: 1953203.
25. Kruglikov IL (2016) Radiofrequente Ströme in der ästhetischen Medizin: Status nascendi / Status quo. Kosmet Med 37(3): 94-103.
